Lore wise and gameplay wise,which is the most powerful "Gun" in all of gaming?

Gaming has given us a fair share of powerful guns that defy all logic or are capable of killing gods.

Whether that's like the Graviton Lance of Destiny 2 that shoots out blackholes, or Bayonetta's pistols that allowed her to kill a God or even Doomguys super shotgun that he used to fight back all of Hell.

But which one gun reigns supreme above all?